As with many long-term medical conditions, Peyronie’s Disease can be not only managed but effectively treated with a range of supplements and remedies. Whilst there are surgical options available to men suffering with Peyronie’s Disease, often these can be incredibly invasive, men can also be left waiting for 12 months or longer for a procedure and even then, the condition can still not always be cured.
Obviously, these medical treatments for the disease are not ideal for any man whose life is being adversely affected by the uncomfortable and impairing condition. However, there are many natural Peyronie’s Disease cures which help deal with and treat the underlying causes of the disease.
Whilst the exact causes of Peyronie’s Disease are not fully understood (more on that later), we know enough to establish which kinds of natural supplements for Peyronie’s Disease will be effective in alleviating symptoms which men suffering from the disease will have.
So, in this article we’re going to explore the best supplements for Peyronie’s Disease and how natural treatments can be just as effective if not more so in dealing with the condition as the risky surgical procedures available. We’ll briefly look at what exactly Peyronie’s Disease is and some of its common causes and symptoms, how natural supplements can make all the difference when it comes to treatment and finally answer some of the web’s most common questions around the disease.
A Brief Explanation Of Peyronie’s Disease
First described in 1561 by Italian anatomists Andreas Vesalius and Gabriele Falloppi, Peyronie’s disease is a condition that affects the penis, causing it to become curved or bent during an erection due to the buildup of fibrous scar tissue. This can result in discomfort, pain, and difficulty with sexual activity.
We have already covered the origins, symptoms and causes of Peyronie’s in a previous article, so we won’t take up too much space discussing it here. If you would like to read more on the condition, you can read our more in-depth guide to Peyronie’s Disease here.
The Common Causes Of Peyronie’s Disease
Peyronie’s disease is generally thought to be caused by injury or trauma to the penis, which can lead to the buildup of fibrous scar tissue. This can occur due to a variety of factors, such as vigorous sexual activity, sports injuries, or accidents. However, there is still much that is unknown about the exact causes of Peyronie’s disease, and researchers continue to study this condition in order to better understand how it develops and identify potential risk factors.
In short, a study from the American Journal of Urology found that the most common causes of Peyronie’s Disease were:
- Penile Trauma (most commonly caused during sexual intercourse)
- Dupuyten’s Disease
- Smoking
- Ageing
The Most Common Symptoms Of Peyronie’s Disease

The symptoms of Peyronie’s disease usually include a significant curvature or bending of the penis during an erection, as well as pain or discomfort during sexual activity or even during everyday activities such as walking or sitting. Some men may also experience a shortening of the penis, a palpable scar or plaque within the penile tissue, and even psychological distress or anxiety related to the changes in their sexual function and physical appearance.
Typically, these symptoms develop over time and they can often be confused with swelling of the penis after injury. In the case that it is just swelling brought on by an injury, this will normally go away within 6 months, whereas Peyronie’s is a lasting condition that WILL NOT go away without treatment. This is one of the main reasons that doctors will wait so long before referring men for penile surgery if they suspect Peyronie’s Disease.
Medications & The Best Supplements For Peyronie’s Disease
Whilst as we have already discussed, there is no outright Peyronie’s Disease cure, there are many medications and supplements which can effectively manage and treat the condition. Typically these supplements and medications focus on addressing the underlying cause of the condition, the build up of fibrinous plaque in the shaft of the penis which causes the painful curvature. We’re going to take a look below at three of the most effective Peyronie’s supplements and medications designed to help manage the condition via oral therapy rather than through invasive surgery.
Neprinol Advanced Fibrin Defence (AFD) Peyronie’s Supplement
Neprinol AFD is a supplement that has shown promise in the treatment of Peyronie’s disease. This natural supplement contains a blend of systemic enzymes that have been shown to help reduce inflammation, break down scar tissue, and support healthy blood flow.
It’s the ingredients of Neprinol AFD which make it one of the best supplements for Peyronie’s Disease. Firstly, the enzyme Serrapeptase, which is part of the Neprinol blend, is derived from the Serratia bacteria found in the intestines of silkworms. This enzyme has been shown to have anti-inflammatory effects and the ability to break down proteins such as fibrin, making it potentially beneficial for conditions that involve inflammation and the buildup of scar tissue, such as Peyronie’s Disease. By breaking down fibrin, serrapeptase may help to reduce the formation of fibrous plaque and improve blood flow to the affected area, which can alleviate symptoms such as pain and curvature of the penis.
Secondly, the other major enzyme present in the Neprinol supplement blend, Nattokinase, another powerful enzyme derived from fermented soybeans, which has been found to have many health benefits, including the ability to break down fibrin. Albeit in a slightly different way to Serrapeptase; Nattokinase attacks the fibrinous build up of plaque in the penis by breaking down proteins in the body, including fibrin and plasmin substrate. When it breaks down these proteins, it can help convert a precursor enzyme called prourokinase into an active enzyme called urokinase, which can help dissolve blood clots and reduce the formation of scar tissue.
Nattokinase can also help increase the amount of tissue plasminogen activator (t-PA), which is another enzyme that helps to break down blood clots. By breaking down these proteins and increasing the amount of active enzymes in the body, Nattokinase can help improve blood flow and reduce inflammation in conditions such as Peyronie’s disease.
Collagenase Clostridium Histolyticum (Xiaflex)
Collagenase Clostridium Histolyticum, often referred to by pharmacists as Xiaflex, is a medication that is used to treat Peyronie’s Disease. Xiaflex focuses on breaking down the collagen fibres that make up the fibrous plaque which causes the curvature of the penis in Peyronie’s Disease. Just like Neprinol AFD, Xiaflex contains an enzyme that specifically targets the collagen protein. This then helps a man’s body to break down the fibrous plaque and restore normal penile function without the need for physical therapies or surgery.
Xiaflex is administered through injection directly into the plaque in the penis, and the treatment typically involves a series of injections over the course of several weeks. However, this can be somewhat more invasive than many men feel comfortable with, hence why oral therapies like Nerinol are much more widely preferred.
It is also worth reflecting on the fact that while Xiaflex can be an effective treatment for Peyronie’s Disease, it may also have side effects, and it is important to discuss the potential risks and benefits with a healthcare provider before starting treatment.
Potassium Para-aminobenzoate (Potaba)
Potassium para-aminobenzoate (which often carries the medical brand name Potaba) is another prescription treatment that is sometimes used for Peyronie’s Disease. Potaba is more similar to Neprinol in that it is a non-invasive oral therapy for the disease and is as such a preferred method of treatment. Its composition is essentially a form of the B vitamin PABA, which has been shown to have anti-inflammatory effects and promote healthy collagen formation.
By reducing inflammation and promoting the growth of healthy tissue, Potba can then in turn help to reduce the curvature of the penis and alleviate symptoms such as pain and discomfort. While Potaba may be effective for some men with Peyronie’s Disease, it is not considered first-line treatment and has been known to take several months of treatment for the affected men to see results. Potaba may also have side effects, such as gastrointestinal discomfort or skin irritation.
Verapamil
Verapamil is a type of calcium channel blocker medication that many GPs and Pharmacists will prescribe to treat Peyronie’s disease. While the exact mechanics behind how it works to treat the condition are not well understood, it is thought that Verapamil may help to break down the fibrous plaque that causes the curvature of the penis, and may also help to reduce inflammation and improve blood flow. Verapamil, like Xiaflex, is typically administered through injection directly into the plaque in the penis, and the treatment typically involves a series of injections over several weeks.
Again, as with the other medications we have listed thus far, it is important to speak with your doctor first as there are potential risks and side effects involved with taking Verapamil for Peyronie’s Disease.
Pentoxifylline
Again, this is another medication which works on the improvement of blood flow and reducing inflammation in its battle against Peyronie’s Disease. Pentoxifylline works by inhibiting an enzyme called phosphodiesterase, which can cause constriction of blood vessels and reduce blood flow to the affected area. By inhibiting this enzyme, Pentoxifylline can help improve blood flow to the penis, which then helps reduce the buildup of scar tissue and alleviate those distressing symptoms such as pain and curvature.
While not only being a suitable treatment for Peyronie’s Disease, pentoxifylline has also been used to treat a variety of other conditions, including peripheral vascular disease and tinnitus.
Vitamin E – Natural Supplements For Peyronie’s Disease
Because Vitamin E carries many anti-inflammatory properties it is sometimes used by men as a natural treatment option for Peyronie’s disease. Before it can be concluded as an effective treatment as the one’s above are, more research is needed. This is mainly for medical professionals to fully understand the potential benefits of Vitamin E for Peyronie’s Disease sufferers. It is believed however, that the antioxidant properties of Vitamin E can help reduce the inflammation and support healthy tissue growth in the penis, this makes it especially helpful in treating Peyronie’s Disease in the early stages.
One study in 2010 by medical researchers in Italy, found that Vitamin E supplementation was effective in reducing curvature of the penis in some men with Peyronie’s disease. The study showed that men who took Vitamin E supplements for six months experienced a significant reduction in the curvature of the penis compared to those who received a placebo.
However, it is important to note that while Vitamin E may be effective for mild and early stage cases of Peyronie’s Disease, it is much less likely to be effective for more severe cases with significant curvature or scar tissue/fibrous plaque build-up. Despite its potential benefits, Vitamin E is unlikely to be effective at treating Peyronie’s Disease in the same way that many of the medications and supplements we have mentioned above are.
Dietary Adjustments for Managing Peyronie’s Disease
It might sound slightly odd, but part of managing Peyronie’s disease can actually start with your diet. Changes in eating and drinking habits alongside traditional treatment methods and supplements like Neprinol really can work wonders. Incorporating anti-inflammatory foods and antioxidants into your diet can significantly impact your body’s ability to combat inflammation and support tissue health and repair. Foods rich in omega-3 fatty acids, such as salmon, flaxseeds, and walnuts, can reduce inflammation throughout the body, potentially easing symptoms associated with Peyronie’s Disease.
On top of these, foods containing vitamins E and C are known for their tissue-repairing properties. Almonds, sunflower seeds, oranges, and strawberries can be excellent sources. These dietary strategies, when combined with Peyronie’s Disease home treatment options, such as specific supplements, can offer a more effective approach in treating Peyronie’s at home.
Using Physical Therapy As A Peyronie’s Disease Home Treatment
Physical therapy is usually what doctors will recommend for Peyronie’s disease, but you can undertake a lot of this in the home. Most people who are looking at how to get rid of fibrous plaque at home, have either ruled out surgery on their penis themselves or been told that they’re not eligible as their case is not severe enough. Usually, this leads to the path of using penile exercises as a Peyronie’s Disease home treatment.
Techniques such as penile stretching exercises and massage therapies can be particularly effective. These exercises aim to gently stretch the penile tissue, promoting flexibility and potentially reducing the curvature caused by Peyronie’s Disease.
Following on, specialised massage techniques can help break down the fibrous plaque, improving blood flow and reducing pain. These physical therapy methods serve as beneficial Peyronie’s Disease home cures, offering patients a way to actively participate in their treatment plan. When combined with supplements known to aid in breaking down fibrous plaque, physical therapy can help move the fibrous plaque once the enzyme supplements have begun breaking it down.

An Analysis Of The Home Treatments For Peyronie’s Disease
When exploring treatments for Peyronie’s Disease, it’s essential to understand the range of options available, from natural supplements and physical therapy to surgical interventions. Each method comes with its own set of advantages and considerations. Supplements and physical therapies represent less invasive Peyronie’s Disease home cure options, focusing on reducing inflammation and plaque buildup with minimal side effects. These approaches can be particularly appealing for those seeking to manage the condition through home treatment for Peyronie’s Disease.
Surgical treatments, while offering a more immediate solution to severe curvature, come with risks such as potential loss of penile length and complications arising from surgery. For those wondering how to get rid of fibrous plaque at home, combining dietary adjustments, physical therapy, and specific supplements might offer a safer alternative to surgery, allowing for gradual improvement of symptoms with fewer risks.





