Neprinol AFD and Lung Disease

Written By Advanced Supplements

On 29 Jul, 2020
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With Neprinol AFD there is new hope for pulmonary fibrosis and interstitial lung diseases sufferers.  A new fibrinolytic enzyme product dissolves scar tissue in the same manner as our digestive enzymes dissolves our food.  

There are more than 100 different diseases that are caused by the buildup of scar tissue in the lungs. Of these numerous interstitial lung diseases (ILDs), the most common is pulmonary fibrosis. Pulmonary fibrosis begins when microscopic damage to the alveoli (air sacs) and interstitial tissues (tissue between cells) of the lungs causes inflammation and scar tissue to develop. As this scar tissue builds up in the lungs it eventually causes the soft, permeable tissue to become stiff and thick, which makes breathing extremely difficult.

Doctors and researchers have identified more than 140 different causes of the initial lung damage that leads to pulmonary fibrosis, ranging from illnesses like sarcoidosis and tuberculosis to inhaling asbestos and other damaging small particles. Even natural substances like mould or enzyme dust can irritate the lungs enough to lead to scar tissue development. Don’t be reluctant to use enzyme supplements for this reason. Enzyme supplements are absorbed into the bloodstream through the digestive system and will not irritate the lungs in this manner.

Still, in the majority of cases of pulmonary fibrosis the exact cause is unknown, which is what idiopathic means. One of the most popular theories is that idiopathic pulmonary fibrosis (IPF) is an autoimmune disease. This means that for some reason the body’s own immune system, which usually protects it from foreign threats like bacteria and viruses, attacks normal, healthy cells instead. The result is significant damage and destruction. In the case of pulmonary fibrosis, this means that the immune system attacks lung cells, destroying them and leaving behind scar tissue.

Neprinol – Enzymes that attack fibrin

Neprinol AFD targets a number of disease-causing mechanisms responsible for fibrosis including inflammation and fibrosis. There are currently no FDA-approved therapies for idiopathic pulmonary fibrosis.  However, the enzymes found in Neprinol have been clinically studied to reduce inflammation and digest scar tissue. Neprinol is a proprietary combination of several natural, protein-degrading enzymes. Neprinol can protect your lungs from the damaging effects of the blood clotting protein called fibrin.  Fibrin is the main component of blood clots, and eventually the residual scar tissue left behind.  Each enzyme in Neprinol has a certain degree of fibrinolytic or “fibrin digesting” capability.  When these enzymes are taken orally they travel through the bloodstream and synergistically liquefy large amounts of fibrin.  Neprinol supports healthy lung elasticity and normal healthy respiratory function.

Cleaning up the blood using neprinol enzymes

Much like digestive enzymes that break down foods, systemic enzymes breakdown and digest waste particles in the bloodstream. When Neprinol is taken on an empty stomach, they these enzymes circulate through the blood removing debris [1-3]. Just like the digestive system needs enzymes, so does our circulatory system. Systemic enzymes like Neprinol purify the blood by digesting circulating immune complexes, blood clots, fibrin, fatty proteins or other unwanted materials that accumulate in the blood.   Circulating immune complexes are antibodies bound to foreign particles, like bacteria and viruses. These circulating immune complexes can cause autoimmune reactions, telling the body to start attacking its own cells.  Impurities cause the blood to thicken and are often treated with dangerous blood thinners. Cleansing the bloodstream can alleviate a toxic build-up of garbage that causes inflammation, and the immune reactions that cause degenerative lung function. Systemic enzymes take a heavy burden off of the immune system, liver and kidneys.

Removing waste material from the bloodstream, while breaking up damaging, inflammation-causing circulating immune complexes calms down the immune system and helps re-establish the body’s natural balance. Using enzymes to modulate the immune system also allows the body to regain its energy levels, reducing fatigue and allowing for the proper repair of damaged lung tissue [4,5].

  • Reduce Inflammation and autoimmune reactions
  • Reduce lung fibrosis and mucus build-up
  • Restore breathing and lung function
  • Remove scar tissue and toxins
  • Reduce C Reactive protein markers
  • Remove circulating immune complexes

Neprinol AFD Enzymes Reducing Inflammation

Another common feature of lung diseases is inflammation. Long-term inflammation can drastically slow down wound healing and increase the likelihood of scar tissue formation. Bromelain, an enzyme extracted from pineapples, can effectively block some of the body’s chemicals that promote the process of inflammation [6-8]. Research has shown that Bromelain is especially effective at decreasing the migration of neutrophils, a type of white blood cell, to inflamed areas. A clinical study measured a 50-85% decrease in neutrophil migration with the use of Bromelain [9]. This is especially important in idiopathic pulmonary fibrosis/IPF since neutrophils are thought to be part of the disease-causing process [10]. That is because once neutrophils reach the site of inflammation, they produce a number of chemical substances that promote both lung injury and scar tissue formation [11].

Nattokinase enzymes dissolving scar tissue

Probably the most important mechanism Neprinol AFD uses in the treatment of IPF and other ILDs is the breakdown of any existing scar tissue and the prevention of future scar formation. This relies on the fibrinolytic (fibrin-dissolving) properties of enzymes like Nattokinase, an enzyme extracted from a popular Japanese fermented soybean food [12,13], and Serrapeptase, an enzyme from silkworms [14].

Some fibrin is needed to help repair the damage done to the lung air sacs and other lung tissue, as it is a vital component of the wound healing process. However, long-term continued fibrin deposits in cases of long-term lung injuries like IPF can lead to the characteristic build-up of scar tissue found in interstitial lung diseases.

Scar tissue becomes an issue when excess fibrin can’t be cleared from the lungs, and it blocks the ability of the lung air sacs to have oxygen pass through into the bloodstream [15]. This build-up of fibrin is thought to be due to the excessive amounts of plasminogen activator inhibitor-1 (PAI-1) identified in patients with idiopathic pulmonary fibrosis (IPF) [16]. PAI-1 prevents the conversation of the protein plasminogen into plasmin, a blood enzyme that degrades many blood proteins, most notably, fibrin. Without plasminogen being converted into plasmin the body’s ability to naturally dissolve fibrin is drastically reduced.

The Nattokinase found in Neprinol can help supplement the body’s natural fibrin-degrading enzymes, since it has fibrin-degrading activity that is four-times more potent than plasmin [17]. Nattokinase works to dissolve fibrin by inactivating PAI-1. By inactivating PAI-1, Nattokinase can allow the excess fibrin to be broken down, which reduces the amount of scar tissue present. Obviously, with the scar tissue reduced or outright removed, the suffocating effects of ILDs will be eliminated as well.

Neprinol a digestive enzyme

Although the enzymes found in Neprinol are formulated to work throughout the body when taken on an empty stomach, their digestive properties may also benefit people with IPF.

Researchers have found that acid reflux disease may be a contributing factor in the development of IPF because stomach acid can cause scarring (build-up of fibrin) when it comes in contact with the trachea, bronchi, and bronchioles of the lungs [18]. In other respiratory diseases like chronic cough or asthma, treating the acid reflux improves the respiratory symptoms. In fact, in one study asthma symptoms improved in 73% of the participants after a course of acid-suppressive therapy [19]  A common cause of acid reflux symptoms is a lack of stomach acid and digestive enzymes. Therefore, the powerful digestive enzymes found in Neprinol, like Bromelain and Papain, can help dissolve proteins, fats and carbohydrates in the stomach and promote a healthy acidic environment.

Other lung diseases

Neprinol is not just beneficial for people with lung diseases caused by scar tissue. Its unique combination of protein-degrading enzymes can also help those with chronic obstructive pulmonary disease (COPD) break down and clear away the mucus that is clogging their lungs [20]. Both Bromelain and Serrapeptase have been shown to reduce the thickness of mucus and help clear it from the lungs, as well as suppressing coughs [8,21]

Some of the dangers of Neprinol

Smokers who take Neprinol may experience wheezing and increased phlegm production. The phlegm could also be yellow or bloody. As the enzyme action of Neprinol takes effect and begins to break down the scar tissue, it also has an expectorant effect, causing the fibrous tissue and tar from smoking to be coughed up and expelled from the lungs. The same issues may occur in people with frequent exposure to chemicals or toxins in the air, such as coal miners. It is great to get the scar tissue or built up toxins out of the lungs. For people that continue to get tar or toxins in their lungs daily due to smoking or work-related hazards, there will be a continuous process of the enzymes removing these hazards and therefore the possibility of continued wheezing or phlegm as long as they take Neprinol.

Why Neprinol Is An effective choice

The fibrin-degrading and inflammation-reducing mechanisms of Neprinol AFD can greatly help those suffering from lung diseases. Though Neprinol has not yet been tested in patients with these illnesses, there is a wealth of published research that provides proof-of-principle evidence for its benefits. Currently there are very few treatment options available to people with ILDs, IPF, COPD, asthma, chronic cough and other lung diseases. And the available medication often comes with unwanted side effects.  Neprinol provides a non-invasive, natural and effective choice without the negative side effects.

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References:

1.  Moriya N, Nakata M, Nakamura M, Takaoka M, Iwasa S, Kato K, Kakinuma A. Intestinal absorption of serrapeptase (TSP) in rats. Biotechnol Appl Biochem 1994;20(Pt 1):101-8.

2.  Erlund I, Kosonen T, Alfthan G, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 2000;56:545-53.

3.  Fujita M, Hong K, Ito Y, Misawa S, Takeuchi N, Kariya K, Nishimuro S. Transport of nattokinase across the rat intestinal tract. Biol Pharm Bull. 1995;18(9):1194-6.

4.  Vokálová I. Systémová enzýmoterapia v liečbe detí s recidivujúcemi respiračními infekcemi.Vox Pediatriae. 2002;2(9):29-30.

5.  Shved MI, Dubkova GI. Therapeutic efficacy of Wobenzym in patients with focal pneumonia. Visnik Naukovych Doslidzenij. 1999(2):79-82.

6.  Onken JE, Greer PK, Calingaert B, et al. Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clin Immunol. 2008;126(3):345-352.

7.  Secor ER, Carson WF, Singh A, et al. Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma. Evid Based Complement Alternat Med. 2008;5(1):61-69.

8.  Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58:1234-1245.

9.  Fitzhugh DJ, Shan S, Dewhirst MW et al. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol. 2008;128:66-74.

10.Mukae H, Iiboshi H, Nakazato M, et al. Raised plasma concentration of alpha-defensins in patients with idiopathic pulmonary fibrosis. Thorax. 2002;57:623-628.

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