Magnesium and enzymes

Magnesium Deficiency

Magnesium and enzymes

It has been suggested that the ideal magnesium content of a healthy illness-free adult is somewhere between 300 and 500 mg. These quantities give a bare margin over the amounts lost daily in the urine, faeces and perspiration. Most therapeutic doses for magnesium are in the in 300 to 600 mg per day range. Other recommendations are that adults should take 6 mg daily for every kg of body weight; so for a person weighing 80 kg this works out at 480 mg. Because of the tremendous importance of magnesium, it appears that the diet of every man, woman and child should be supplemented with this nutrient unless he is lucky enough to eat foods grown entirely on magnesium-rich soils without chemical fertilizers.


Magnesium is needed by every cell in the body including those of the brain and is one of the most important minerals when considering supplementation because of its vital role in hundreds of enzyme systems and functions related to reactions in cell metabolism, as well as being essential for the synthesis of proteins, for the utilization of fats and carbohydrates. Magnesium is needed not only for the production of specific detoxification enzymes but is also important for energy production related to cell detoxification. A magnesium deficiency can affect virtually every system of the body.

One of the principle reason doctors write millions of prescriptions for tranquilizers each year is the nervousness, irritability, and jitters largely brought on by inadequate diets lacking magnesium.Persons only slightly deficient in magnesium become irritable, highly-strung, and sensitive to noise, hyper-excitable, apprehensive and belligerent. If the deficiency is more severe or prolonged, they may develop twitching, tremors, irregular pulse, insomnia, muscle weakness, jerkiness and leg and foot cramps. If magnesium is severely deficient, the brain is particularly affected. Clouded thinking, confusion, disorientation, marked depression and even the terrifying hallucinations of delirium tremens are largely brought on by a lack of this nutrient and remedied when magnesium is given. Because large amounts of calcium are lost in the urine when magnesium is under supplied, the lack of this nutrient indirectly becomes responsible for much rampant tooth decay, poor bone development, osteoporosis and slow healing of broken bones and fractures. With vitamin B6 (pyridoxine), magnesium helps to reduce and dissolve calcium phosphate kidney stones.

Often, a magnesium deficiency can be synonymous with diabetes. Magnesium deficiencies are at the root of many cardiovascular problems. Magnesium deficiency may be a major cause of fatal cardiac arrhythmia, hypertension, and sudden cardiac arrest, as well as asthma, chronic fatigue, chronic pain syndromes, depression, insomnia, irritable bowel syndrome, and pulmonary disorders. (Balk)

Chronic sub-optimal dietary intakes are known to be implicated in the development of several disease states, including asthma, osteoporosis and Syndrome X as well as chronic fatigue syndrome, fibromyalgia and most forms of PMS.

But by being on the lookout for the early stage symptoms of magnesium insufficiency, it is more than likely that these more serious later stage pathologies can be avoided altogether.


Suggestive early warning signs of magnesium deficiency:


  • Physical and mental fatigue
  • Persistent under-eye twitch
  • Tension in the upper back, shoulders and neck
  • Headaches
  • Pre-menstrual fluid retention and/or breast tenderness


Possible manifestations of magnesium deficiency include:


  • Low energy
  • Fatigue
  • Weakness
  • Confusion
  • Nervousness
  • Anxiousness
  • Irritability
  • Seizures (and tantrums)
  • Poor digestion
  • PMS and hormonal imbalances
  • Inability to sleep
  • Muscle tension, spasm and cramps
  • Calcification of organs
  • Weakening of the bones
  • Abnormal heart rhythm


Magnesium deficiency is associated with an increased incidence of:


  • Hypertension
  • Cardiac arrhythmias
  • Heart attacks
  • Atherosclerosis
  • Diabetes


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